There are certain medications that interact with food. You do not have to check with your doctor every time you make a new recipe, you just need to check with your doctor before you get started. Certain cholesterol medications may interact with grapefruit or other fruits. Coumadin can interact with dark leafy greens. When you are on medications and starting a new eating routine, it is best to double check with your doctor. If you are blending foods that you are eating on a regular basis, you should be fine but it is always best to double check.