This depends on your health goal. If Blasting for weight loss you will want to be mindful of the total amount of calories consumed (Blast and additional foods combined). It is fine to save some that you would have added to your Blast to eat on the side if you'd like something to chew. A Blast is technically still food...just in liquid form so taking your vitamins with a Blast should be fine (since I am not sure exactly what type of vitamins you are taking just double check w/ your Dr.). For weight loss I'd advise against added fruit outside of Blasting.